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While little is known on the sex differences in MTHFR polymorphisms, sex hormones, such as estrogen is known to play a protective effect in female patients with schizophrenia as for the impact of neurodevelopment and social maturation 55

At a molecular level, MET cKO mice showed altered glutamate receptor expression profiles in the hippocampus at P14, including increased GluA1, GluN2A, and decreased GluN2B at the synaptic sites